OAK BROOK, Ill.--(BUSINESS WIRE)--June 16, 2006--Bio-Bridge Science, Inc. (OTCBB: BGES - News), a developer of vaccines with broad preventative and therapeutic applications, today announced that the Beijing Institute of Radiation Medicine has notified the Company that it has completed the planned pre-clinical safety and immunogenicity studies for Bio-Bridge's oral HIV vaccine. In early February, Bio-Bridge Science received encouraging initial results of the pre-clinical trials.
Final results show no toxicity was observed in the animals orally administered with the HIV vaccine. There is no indication that vaccine DNA integrates into host genome and passes through placenta barrier. The immunogenicity study in monkeys shows that the vaccine induces HIV-1 gp41-specific serum antibodies (IgG) and intestinal and vaginal antibodies (sIgA). The sera, intestinal and vaginal washings neutralize HIV-1 primary isolate in vitro. The vaccine also induces HIV-1 Gag-specific T cells in the vaccinated monkeys.
"We are very pleased that the Beijing Institute of Radiation Medicine has reported favorable safety and immunogenicity data on our oral HIV vaccine," commented Liang Qiao, M.D., Chairman and CEO of Bio-Bridge Science. "It is a major milestone in the development of our HIV vaccine."
Based on these favorable results, the company is expected to file application for clinical trials with the Chinese FDA in the near future.
"Source":[ http://biz.yahoo.com/bw/060616/20060616005195.html?.v=1]
Scientists Unveil Piece Of HIV Protein That May Be Key To AIDS Vaccine Development -
In a finding that could have profound implications for AIDS vaccine design, researchers led by a team at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), have generated an atomic-level picture of a key portion of an HIV surface protein as it looks when bound to an infection-fighting antibody (20.2.2007)
Researchers seek to solve mystery of natural HIV control -
In search of new vaccine strategies, study will examine genetics, immune systems of those able to suppress viral replication
An international, multi-institutional research consortium is seeking to discover how a few HIV-infected individuals are naturally able to suppress replication of the virus (26.8.2006)
