Bacteria in the Gut May Influence Brain Development
Date: 3.2.2011
A team of scientists from around the globe have found that gut bacteria may influence mammalian brain development and adult behavior. The study is published in the scientific journal PNAS, and is the result of an ongoing collaboration between scientists at Karolinska Institutet in Sweden and the Genome Institute of Singapore.
The research team compared behavior and gene expression in two groups of mice -- those raised with normal microorganisms, and those raised in the absence of microorganisms (or germ-free mice). The scientists observed that adult germ-free mice displayed different behavior from mice with normal microbiota, suggesting that gut bacteria may have a significant effect on the development of the brain in mammals.
The adult germ-free mice were observed to be more active and engaged in more 'risky' behavior than mice raised with normal microorganisms. When germ-free mice were exposed to normal microorganisms very early in life, as adults they developed the behavioral characteristics of those exposed to microorganisms from birth. In contrast, colonizing adult germ-free mice with bacteria did not influence their behavior.
Original Paper:
R. D. Heijtz, S. Wang, F. Anuar, Y. Qian, B. Bjorkholm, A. Samuelsson, M. L. Hibberd, H. Forssberg, S. Pettersson. Normal gut microbiota modulates brain development and behavior. Proceedings of the National Academy of Sciences, 2011; DOI: 10.1073/pnas.1010529108
Source:
http://ki.se/ki/jsp/polopoly.jsp?d=130&a=115860&l=en&newsdep=130
