Cardiac Patch Constructed from Human Fibroblasts Attenuates
Date: 7.2.2006
The current experiments used a scaffold-based, three-dimensional, human dermal fibroblast culture
(3DFC) as a cardiac patch to stimulate revascularization and preserve left ventricular (LV)
function of the infarcted LV in severe combined immunodeficient (SCID) mice. The 3DFC contains
viable cells that secrete angiogenic growth factors and has been previously shown to stimulate angiogenesis.
The hypothesis tested was that a 3DFC cardiac patch would attenuate a reduction in LV
function of infarcted hearts.
"Source": http://www.liebertonline.com/doi/pdf/10.1089/ten.2005.11.1678]
