Japanese woman is first recipient of next-generation stem cells
Date: 18.9.2014
Surgeons implanted retinal tissue created after reverting the patient's own cells to 'pluripotent' state.
A Japanese woman in her 70s is the first person to receive tissue derived from induced pluripotent stem cells, a technology that has created great expectations since it could offer the same regenerative potential as embryo-derived cells but without some of the ethical and safety concerns.
In a two-hour procedure starting at 14:20 local time today, a team of three eye specialists lead by Yasuo Kurimoto of the Kobe City Medical Center General Hospital, implanted a 1.3 by 3.0 millimetre sheet of retinal pigment epithelium cells into an eye of the Hyogo prefecture resident, who suffers from age-related macular degeneration, a common eye condition that can lead to blindness.
The procedure took place at the Institute for Biomedical Research and Innovation, next to the RIKEN Center for Developmental Biology (CDB), where ophthalmologist Masayo Takahashi had developed and tested the epithelium sheets. Takahashi had reprogrammed some cells from the patient's skin to produce induced pluripotent stem (iPS) cells. She then coaxed those cells to differentiate into retinal pigment epithelium cells and grow into a sheet for implantation.
The patient had no effusive bleeding or other serious problems after the surgery, RIKEN reported.
