Microbicide Containing Engineered Bacteria May Inhibit HIV-1
Date: 4.8.2010
Researchers from the U.S. and abroad used bacteria inherent to the **human vaginal tract** to develop a live, topical **microbicide** that may induce production of HIV-1 protein inhibitors and ultimately prevent transmission of the **virus**.
In the study researchers engineered a human vaginal isolate of **Lactobacillus jensenii** capable of generating the anti-HIV-1 proteins RANTES and CIC5 RANTES which oppose the HIV-1 receptor protein, CCR5. Both RANTES variants inhibited HIV-1 infection and demonstrated significant activity against various **HIV-1** genetic subtypes.
More on "American Society for Microbiology":[ http://www.asm.org/index.php/what-s-new/microbicide-containing-engineered-bacteria-may-inhibit-hiv-1.html]
