New Discoveries in Diabetes Suggest Novel Ways to Treat, Delay the Disease

A study conducted by researchers at Karolinska Institutet's Department of Molecular Medicine and Surgery presents a possible method of delaying the disease.

Type I diabetes coincides with high blood concentrations of the lipoprotein apolipoprotein CIII (ApoCIII). The team has now demonstrated on rats, which develop a form of type I diabetes analogous to the human kind, that levels of Apo CIII are raised before the onset of the disease and that this causes the insulin producing beta cells to die.

By reducing the production of ApoCIII using antisense therapy, the researchers succeeded in significantly delaying the onset of diabetes to the extent that it took twice as long for the rats to develop the disease.

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