Polymer nanoparticle overcomes anticancer drug resistance

In a nanotechnology two-for-one, researchers at the Johns Hopkins University Center of Cancer Nanotechnology Excellence (Hopkins CCNE) have created a polymer nanoparticle that overcomes tumor resistance to the common anticancer agent doxorubicin and that protects the heart against drug-triggered damage, a therapy-ending side effect that limits doxorubicin's effectiveness. This novel nanoparticle incorporates both doxorubicin and curcumin, a major component of the bright yellow spice turmeric.

Both in vitro and animal tests demonstrated that this formulation had striking anticancer activity in models of multiple myeloma, leukemia, and prostate and ovarian cancers. Perhaps equally important, the animals treated with the nanoparticle did not experience any cardiac toxicity or bone marrow suppression, even at cumulative doses that normally trigger cardiac toxicity by free doxorubicin or liposome-encapsulated doxorubicin, which was the first nanoparticle drug approved for use in treating cancer in humans and is widely used in treating breast cancer.

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