postdoc in the Laboratory of Cell Differentiation, Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.

Type of job: full-time

We investigate regulation of cancerogenesis at cellular and molecular level with focus on metastatic dissemination and therapy resistence of cancer cells (namely breast and colon carcinomas). We also test new compounds with anti-cancer activity. Our research is based on tissue culture experiments (2D and 3D) with established and primary cancer cell lines and in vivo mouse models. We also participate in clinical studies.

Requirements:

• PhD in molecular biology, biochemistry, or similar
• High motivation
• Ability to formulate hypothesis
• Publishing activity corresponding to given career stage
•  Experience with tissue culture and molecular biology methods

We offer:

• engagement in funded projects (GAČR, AZV, OP VVV)
• well equipped laboratories
• in-house core facilities
• background of a recognized institution
• participation in teaching
• possibility to start independent career

 Anticipated start date: Fourth quarter of 2019

Please send application (including CV, motivation letter, contact information and at least two references) by email to pbenes@sci.muni.cz

Electronic application deadline is: September 15th, 2019

Selected papers of the laboratory:

1.  Knopfová L, Biglieri E, Volodko N, Masařík M, Hermanová M, Glaus Garzón JF, et al. Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding.Oncogene. 2018; 37: 1020-1030.
2. Kučírková T, Stiborek M, Dúcka M, Navrátilová J, Bogdanović Pristov J, Popović-Bijelić A, et al. Anti-cancer effects of wedelolactone: interactions with copper and subcellular localization.Metallomics. 2018; 10: 1524-1531.
3. Navrátilová J, Karasová M, Kohutková Lánová M, Jiráková L, Budková Z, et al. Selective elimination of neuroblastoma cells by synergistic effect of Akt kinase inhibitor and tetrathiomolybdate. J Cell Mol Med. 2017; 21: 1859-1869.
4. Pekarčíková L, Knopfová L, Beneš P, Šmarda J. c-Myb regulates NOX1/p38 to control survival of colorectal carcinoma cells.Cell Signal. 2016; 28: 924-36.
5. Knopfova L, Beneš P, Pekarcikova L, Hermanova M, Masarik M, Pernicova Z, et al. c-Myb regulates matrix metalloproteinases 1/9 and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis. Mol Cancer 2012; 11: 15.
6. Beneš et al., Inhibition of topoisomerase IIa: Novel function of wedelolactone, Cancer Lett. (2011), doi:10.1016/j.canlet.2011.01.002

Contact:
Petr Beneš, PhD

E-mail:
pbenes@sci.muni.cz

WWW:
https://www.sci.muni.cz/LCD/

Updated: 9.8.2019