Protective efficiency of dendrosomes as novel nano-sized adjuvants for DNA vaccination against birch pollen allergy
Date: 5.4.2006
Researchers evaluated the use of a novel gene porter (Den123-a nontoxic self-assembled dendritic spheroidal nanoparticle made of biodegradable monomers), aiming to enhance and improve the desired immune response in protection from allergy.
Footpad DNA immunization in Balb/c mice was done three times using the Bet v 1a gene with or without Den123 with 2-week intervals followed by sensitization with rBetv1 (5 μg) in alum twice in a weekly interval. All DNA-pre-immunized mice demonstrated low basophil degranulation. It is therefore concluded that administration of the DNA entrapped in Den123 nanoparticles results in sustained release of plasmids, Th1/Th2 balanced immune response with promising IgE inhibition.
"Source":[ http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T3C-4JD0GVG-7&_coverDate=03%2F03%2F2006&_alid=379231874&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=4943&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3d851b6dddd3791c2d36fd25d9c6e94d
].
