Scientists discover new antibiotic in tropical forest

Scientists from Rutgers University and around the world have discovered an antibiotic produced by a soil bacterium from a Mexican tropical forest that may help lead to a "plant probiotic," more robust plants and other antibiotics.

Probiotics, which provide friendlier bacteria and health benefits for humans, can also be beneficial to plants, keeping them healthy and more robust. The new antibiotic, known as phazolicin, prevents harmful bacteria from getting into the root systems of bean plants.

"We hope to show the bacterium can be used as a 'plant probiotic' because phazolicin will prevent other, potentially harmful bacteria from growing in the root system of agriculturally important plants," said senior author Konstantin Severinov, a principal investigator at the Waksman Institute of Microbiology and a professor of molecular biology and biochemistry in the School of Arts and Sciences at Rutgers University-New Brunswick. "Antibiotic resistance is a huge problem in both medicine and agriculture, and continuing searches for new antibiotics are very important as they may provide leads for future anti-bacterial agents."

The bacterium that produces phazolicin, is an unidentified species of Rhizobium. It was found in a tropical forest in Los Tuxtlas, Mexico, in the soil and roots of wild beans called Phaseolus vulgaris, hence the antibiotic's name: phazolicin. Like other Rhizobia, the phazolicin-producing microbe forms nodules on bean plant roots and provides plants with nitrogen, making them grow more robustly than others. Unlike other Rhizobia, it also defends plants from harmful bacteria sensitive to phazolicin.