Structural proteins of retroviruses
Date: 26.3.2007
Mason-Pfizer Monkey Virus (M-PMV) is characterized by the assembly of intracytoplasmic immature particles, which are afterwards transported to the plasma membrane and are released by budding. This makes M-PMV valuable model as the assembly of the virion and its budding are spatially distinct processes. We are focused mainly on the MA and p12 proteins, which are playing critical role in the process of assembly and transport.. The work comprises of the construction of the vectors encoding the retroviral protein, bacterial expression of the proteins and their purification. Proteins prepared are then studied by NMR or X-ray crystallography.
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