Study of alligator dental regeneration process may lead to tooth regeneration in humans

A team of researchers from the U.S., Taiwan and China analyzing tooth regeneration in alligators reports that a similar process might possibly be instigated in humans through artificial means.

In their paper published in the PNAS, the team describes how they uncovered the tooth regeneration process in alligators and why it might apply to human dentistry. Scientists have long known that tooth regeneration occurs in alligators, but until now, most believed the process followed a schedule—like snakes shedding their skin or birds molting. This new research indicates that the process is actually an on-demand system—when a tooth is lost, a new tooth re-grows in its place. This is an exciting development because alligator tooth structure is very similar to human tooth structure.

To find out what actually occurs with alligator tooth replacement, the research team used a variety of techniques (x-rays, tissue analysis, etc.) to study the tooth structure of embryonic, hatchling and three year old alligators.

They found that the structure was made up of three parts: a mature tooth, an immature replacement tooth-in-waiting and tissue with stem cells in it. By extracting teeth from a juvenile they were able to watch the tooth replacement process in action. They found that upon loss of a tooth, the tooth-in-waiting began to mature and the tissue with stem cells in it formed a bulge that over time caused the development of a new tooth-in-waiting. The process in alligators is so effective, the researchers found, that all of their 80 teeth are replaced an average of 50 times over their lifetime.