Superbug MRSA arose in hedgehogs long before clinical use of antibiotics

Staphylococcus aureus first developed resistance to the antibiotic methicillin around 200 years ago, according to a large international collaboration including the University of Cambridge, the Wellcome Sanger Institute, Denmark's Serum Statens Institut and the Royal Botanic Gardens, Kew, which has traced the genetic history of the bacteria.

They were investigating the surprising discovery from hedgehog surveys from Denmark and Sweden - that up to 60% of hedgehogs carry a type of MRSA called mecC-MRSA. The new study also found high levels of MRSA in swabs taken from hedgehogs across their range in Europe and New Zealand.

The researchers believe that antibiotic resistance evolved in Staphylococcus aureus as an adaptation to having to exist side-by-side on the skin of hedgehogs with the fungus Trichophyton erinacei, which produces its own antibiotics.

The resulting methicillin-resistant Staphylococcus aureus is better known as the superbug MRSA. The discovery of this centuries-old antibiotic resistance predates antibiotic use in medical and agricultural settings.

MRSA was first identified in patients in 1960, and around 1 in 200 of all MRSA infections are caused by mecC-MRSA. Due to its resistance to antibiotics, MRSA is much harder to treat than other bacterial infections. The World Health Organization now considers MRSA one of the world's greatest threats to human health. It is also a major challenge in livestock farming.

https://phys.org/news/2022-01-superbug-mrsa-arose-hedgehogs-clinical.html