Vitamin E Trials 'Fatally Flawed'

**Generations of studies on vitamin E may be largely meaningless, scientists say, because new research has demonstrated that the levels of this micronutrient necessary to reduce oxidative stress are far higher than those that have been commonly used in clinical trials.** In a new study and commentary in **Free Radical Biology and Medicine**, researchers concluded that the levels of **vitamin E** necessary to reduce oxidative stress ? as measured by accepted biomarkers of lipid peroxidation ? are about 1,600 to 3,200 I.U. daily, or four to eight times higher than those used in almost all past clinical trials. This could help explain the inconsistent results of many **vitamin E trials** for its value in preventing or treating **cardiovascular disease**, said Balz Frei, professor and director of the Linus Pauling Institute at Oregon State University, and co-author of the new commentary along with Jeffrey Blumberg, at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. Whole article on "BIO":[ http://www.bio.com/newsfeatures/newsfeatures_research.jhtml;jsessionid=E0VJ3RPBCQBLJR3FQLMSFEWHUWBNQIV0?cid=33900001]

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