What makes the durian fruit stink? Cancer scientists crack the durian genome
Date: 16.10.2017
Singaporean scientists and international collaborators have achieved a world's first by deciphering the complete genetic map of durian, a prized tropical fruit delicacy known in Asia as the "king of fruits." The Singapore team's efforts were driven by both innate scientific curiosity and a love of the fruit.
"Being a geneticist, I was naturally curious about the Durian genome-what gene causes its pungent smell? How did its spiny husk arise?" said study co-author Professor Teh Bin Tean, a durian lover and currently the deputy director of the National Cancer Centre Singapore.
Using state-of-the-art sequencing platforms, the team mapped the genome of a particular durian variety called Musang King ("Mao Shan Wang" in Chinese), known for its exceptionally delicate texture and potent aroma and considered as the King of Kings in the local durian world. The team's analysis revealed that the durian genome comprises approximately 46,000 genes -almost double that in humans, who have about 23,000 genes. Based on the newly generated genomic data, the team also studied the evolution of durian and traced its relationship 65 million years back to the cacao plant, which produces chocolate.
The team also focused on the million-dollar question -what causes the durian's notorious smell? By comparing gene activity patterns from different parts of the durian plant, including leaves, roots and ripening fruits, they identified a class of genes called MGLs (methionine gamma lyases) that regulate the production of odour compounds called volatile sulfur compounds (VSCs).
"Our analysis revealed that VSC production is turbocharged in durian fruits, which fits with many people's opinions that durian smell has a 'sulphury' aspect," said co-lead author Professor Patrick Tan from Duke-NUS Medical School. The team speculates that in the wild, the ability of durians to produce high VSC levels and a pungent smell may be important in attracting animals to eat and disperse durian seeds to other regions.
