Chorionic villus sampling (CVS) is a form of prenatal diagnosis to determine chromosomal or genetic disorders in the fetus. It entails sampling of the chorionic villus (placental tissue) and testing it for chromosomal abnormalities, usually with FISH or PCR.
CVS was performed for the first time by Italian biologist Giuseppe Simoni, scientific director of Biocell Center, in 1983.
It can be performed in a transcervical or transabdominal manner.
Although this procedure is mostly associated with testing for Down Syndrome, overall, CVS can detect more than 200 disorders.
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